Clinical Utility of Quantitative Imaging

Utility of multispectral imaging in automated quantitative scoring of immunohistochemistry.

BACKGROUND Automated scanning devices and image analysis software provide a means to overcome the limitations of manual semiquantitative scoring of immunohistochemistry. Common drawbacks to automated imaging systems include an inability to classify tissue type and an inability to segregate cytoplasmic and nuclear staining. METHODS Immunohistochemistry for the membranous marker α-catenin, the ...

Quantitative Imaging in Clinical Trials

Clinical utility of imaging for evaluation of hepatocellular carcinoma

The hemodynamics of a hepatocellular nodule is the most important imaging parameter used to characterize various hepatocellular nodules in liver cirrhosis, because sequential changes occur in the feeding vessels and hemodynamic status during hepatocarcinogenesis. Therefore, the imaging criteria for hepatocellular carcinoma (HCC) are also usually based on vascular findings, eg, early arterial up...

Quantitative Biomedical Imaging: Techniques and Clinical Applications

1Medical and Health Physics Program, Department of Physics and Astronomy, Louisiana State University, Baton Rouge, LA 70803, USA 2Laboratory of Metabolism-Body Composition, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA 3Department of Radiology, Johns Hopkins University, Baltimore, MD 21287, USA 4Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China...

Quantitative Imaging in Cancer Clinical Trials.

As anticancer therapies designed to target specific molecular pathways have been developed, it has become critical to develop methods to assess the response induced by such agents. Although traditional, anatomic CT, and MRI examinations are useful in many settings, increasing evidence suggests that these methods cannot answer the fundamental biologic and physiologic questions essential for asse...